Age-related changes in H2O2 production and bioenergetics in rat brain synaptosomes

Age-related changes in rat retina.

PURPOSE To describe the changes in rat retina occurring with ageing by means of histological methods, scanning electron microscopic observations and morphometrical data; and to study by means of biochemical methods the amount of protein content in retinal tissues. METHODS Samples of fresh retinal tissue obtained from young, adult, and aged rats were studied by means of traditional histologica...

Acute lead toxicity and energy metabolism in rat brain synaptosomes.

Although the neurotoxic effects of lead (Pb) are well documented, the subcellular mechanisms of its action in the central nervous system are not fully understood. The present work examined some parameters of energy metabolism in nerve endings of the brains of adult rats exposed to Pb. We applied the model of acute Pb toxicity in vivo, imitating the acute action of lead observed in occupationall...

Neuropathological Changes in Brain Cortex and Hippocampus in a Rat Model of Alzheimer’s Disease

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. The aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of AD. Methods: Adult male Albino Wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. The rats were randomly assigned t...

Neomycin inhibits K+- and veratridine-stimulated noradrenaline release in rat brain slices and rat brain synaptosomes.

The possible involvement of phosphoinositides' turnover in the process of neurotransmitter release in the central nervous system (CNS) was studied using rat brain slices and synaptosomes. A depolarizing concentration of potassium chloride (25 mM) induces an 8.6 +/- 0.4% increase of [3H]noradrenaline [( 3H]NA) fractional release in cerebral cortical slices above spontaneous release, and 15 mM KC...

Age-related changes in the expression of ER-β mRNA in the female rat brain